Antimicrobial Guidelines

The South Australian expert Advisory Group on Antimicrobial Resistance (SAAGAR) has developed evidence-based, peer-reviewed guidelines relating to best practice standards in antimicrobial usage. By optimising use of antimicrobials, adverse events including the development of antimicrobial resistance can be minimised.

These guidelines are designed to be used in conjunction with Therapeutic Guidelines: Antibiotic Version 16 developed by Therapeutic Guidelines Limited (TGL), an independent not-for-profit organisation.

Further guidelines will be added to this site as they become available.

Antimicrobial alerts regarding national shortage

Tinidazole

See the following for more information related to antimicrobial shortages:

SAAGAR position statements

Guidelines from the National COVID-19 Clinical Evidence Taskforce

A national COVID-19 Clinical Evidence Taskforce has been established to undertake continuous evidence surveillance and synthesis to provide national, evidence-based guidelines for the clinical care of patients with COVID-19. These 'living' guidelines are continually updated weekly. Please note that antimicrobials included in the guideline or evidence summaries may not be on the SA hospital formulary - prescribers should check the formulary status before prescribing in SA public hospitals.

Surgical antibiotic prophylaxis guidelines

Surgical antibiotic prophylaxis is an accepted part of surgical practice to prevent infections at the surgical site and optimise post-operative recovery. The statewide Surgical Antibiotic Prophylaxis Clinical Guideline (PDF 1.40MB) has been developed by SAAGAR to assist clinicians with recommendations on appropriate antibiotic dosage and administration, risks and contraindications and post-operative care for a range of surgical procedures.

Guideline appendices

The recommended antimicrobial prophylaxis regimens for specific surgical procedures, along with alternatives for patients with a high risk of penicillin/cephalosporin allergy, are available in the Surgical Antibiotic Prophylaxis Clinical Guideline (PDF 1.40MB) appendices 1 to 17.

Prescribing guidelines

Aminoglycosides: recommendations for use, dosing and monitoring (PDF 152KB) - prescribing guideline for the safe and effective use of aminoglycoside antibiotics.

Antimicrobial prescribing clinical guideline (PDF 356KB) – provides general principles when prescribing antimicrobials for patients with, or risk of, infection.

Community acquired pneumonia (adults) management clinical guideline (PDF 275KB) – provides advice to assist prescribers to identify and initiate empirical antimicrobial therapy for suspected community acquired pneumonia (CAP) in adult patients.

Diabetic foot infections antibiotic management clinical guideline (PDF 1.16MB) - provides advice on the appropriate empiric antimicrobial treatment based on the assessment of the severity of foot infections and the likely pathogens involved.

Empirical treatment of bacterial urinary tract infection (UTI) clinical guideline (PDF 301KB) – provides advice on the initial empirical antimicrobial therapy for urinary tract infections in adult patients.

Febrile neutropenia management (adults) clinical guideline (PDF 313KB) – provides advice on the best practice in the initial management of febrile neutropenia in adult patients. The febrile neutropenia emergency letter (PDF 176KB) provides instruction for prompt assessment and treatment of patients at risk.

Hospital-acquired Pneumonia and Ventilator-associated Pneumonia (Adults) Clinical Guideline (PDF 733KB) - guide the management of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP.)

Intravenous to oral switch clinical guideline for adult patients – can antibiotics S.T.O.P. (PDF 175KB) – provides recommendations for the appropriate and timely switching of intravenous antimicrobials to an oral equivalent.

Sepsis Kills is a suite of resources for treatment of sepsis. This is available from the NSW Clinical Excellence Commission.

Splenectomy Vaccination and Antimicrobial Prophylaxis (Adult Asplenic and Hyposplenic Patients) Clinical guideline (PDF 817KB) and The SA Health Post-splenectomy treatment consumer information (PDF 322KB) – provides recommendations for the care of patients in order to protect them from overwhelming post-splenectomy infections (OPSI).

Staphylococcus aureus bacteraemia (SAB) management (adult) clinical guideline (PDF 363KB) - to assist decision making around antimicrobial prescribing, investigations and duration of therapy.

Vancomycin dosing and monitoring clinical practice guideline (PDF 379KB) - provides statewide directive on the safe and effective use of vancomycin in adults.

Paediatric guidelines

The AMS committee at Women's and Children's Hospital have developed a number of prescribing guidelines and resources for paediatric patients. For access to these resources please contact SA Health's Infection Control Service.

[Note SA Health employees can access these resources through the Women's and Children's Hospital Intranet site].

Fact sheets

Understanding and interpreting minimum inhibitory concentrations (MIC) and breakpoint (PDF 82KB)

Understanding and interpreting pharmacokinetic (PK) and pharmacodynamic (PD) targets for antimicrobial (PDF 82KB)

Dosing of antimicrobials for obese patients (PDF 132KB)

It's about time: Antibiotic Duration (PDF 253KB)

Further information

For further information on antimicrobial guidelines contact SA Health’s Infection Control Service