Progressive Supranuclear Palsy (PSP or Steele-Richardson-Olseweski syndrome) is a rapidly degenerative neurological disorder.
The prevalence of PSP is 6.5 per 100,000 (similar to Motor Neuron Disease)
average age of onset is 60 to 65 years
average life expectancy is six to seven years from diagnosis.
PSP belongs to the family of tauopathies. Abnormalities in the protein tau lead to damage in both cortical and subcortical areas of the brain.
PSP is difficult to diagnose.
Patients may remain undiagnosed for approximately half of the natural history of their disease.
Patients with PSP present with parkinsonian symptoms of slowness of movement, difficulty initiating movement, and rigidity with or without resting tremor. PSP differs from Parkinson’s Disease with rapid progression of their disorder, absent/poor/waning response to dopaminergic medications, early instability or falls, early dysphagia and/or dysarthria.
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