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All rights reserved. INFORMAL COPY WHEN PRINTED Page 1 of 14 Public-I4-A4 Note: This guideline provides advice of a general nature. This statewide guideline has been prepared to promote and facilitate standardisation and consistency of practice, using a multidisciplinary approach. The guideline is based on a review of published evidence and expert opinion. Information in this statewide guideline is current at the time of publication. SA Health does not accept responsibility for the quality or accuracy of material on websites linked from this site and does not sponsor, approve or endorse materials on such links. Health practitioners in the South Australian public health sector are expected to review specific details of each patient and professionally assess the applicability of the relevant guideline to that clinical situation. If for good clinical reasons, a decision is made to depart from the guideline, the responsible clinician must document in the patient s medical record, the decision made, by whom, and detailed reasons for the departure from the guideline. This statewide guideline does not address all the elements of clinical practice and assumes that the individual clinicians are responsible for discussing care with consumers in an environment that is culturally appropriate and which enables respectful confidential discussion. This includes: The use of interpreter services where necessary, Advising consumers of their choice and ensuring informed consent is obtained, Providing care within scope of practice, meeting all legislative requirements and maintaining standards of professional conduct, and Documenting all care in accordance with mandatory and local requirements Explanation of the aboriginal artwork: The aboriginal artwork used symbolises the connection to country and the circle shape shows the strong relationships amongst families and the aboriginal culture. The horse shoe shape design shown in front of the generic statement symbolises a woman and those enclosing a smaller horse shoe shape depicts a pregnant women. The smaller horse shoe shape in this instance represents the unborn child. The artwork shown before the specific statements within the document symbolises a footprint and demonstrates the need to move forward together in unison. Purpose and Scope of Perinatal Practice Guideline (PPG) To guide clinicians with the management of women and their newborns who are at risk of, or are found to have, vitamin D insufficiency/deficiency in pregnancy. Australian Aboriginal Culture is the oldest living culture in the world yet Aboriginal people continue to experience the poorest health outcomes when compared to non-Aboriginal Australians. In South Australia, Aboriginal women are 2-5 times more likely to die in childbirth and their babies are 2-3 times more likely to be of low birth weight. The accumulative effects of stress, low socio economic status, exposure to violence, historical trauma, culturally unsafe and discriminatory health services and health systems are all major contributors to the disparities in Aboriginal maternal and birthing outcomes. Despite these unacceptable statistics the birth of an Aboriginal baby is a celebration of life and an important cultural event bringing family together in celebration, obligation and responsibility. The diversity between Aboriginal cultures, language and practices differ greatly and so it is imperative that perinatal services prepare to respectively manage Aboriginal protocol and provide a culturally positive health care experience for Aboriginal people to ensure the best maternal, neonatal and child health outcomes. Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 2 of 14 Public-I2-A2 Flowchart 1: Management of Vitamin D Status in Pregnancy Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 3 of 14 Public-I2-A2 Flowchart 2: Newborn Management Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 4 of 14 Public-I2-A2 Table of Contents Purpose and Scope of Perinatal Practice Guideline (PPG) ............................................................ 1 Flowchart 1: Management of Vitamin D Status in Pregnancy ......................................................... 2 Flowchart 2: Newborn Management ............................................................................................... 3 Abbreviations ................................................................................................................................... 5 Definitions ........................................................................................................................................ 5 Introduction ...................................................................................................................................... 5 Food sources of Vitamin D .......................................................................................................... 5 Other sources of Vitamin D ......................................................................................................... 5 Vitamin D content of multivitamins .............................................................................................. 6 Vitamin D status in pregnancy ......................................................................................................... 6 Antenatal screening and treatment ................................................................................................. 7 First appointment (booking) screening of at risk women ............................................................. 7 Vitamin D supplementation for ALL pregnant women ................................................................. 7 First follow-up of at risk women ................................................................................................... 7 Subsequent follow-up of at risk women ....................................................................................... 7 Discharge ..................................................................................................................................... 7 Neonatal management .................................................................................................................... 8 References ...................................................................................................................................... 9 Appendix I: Fact Sheet: Vitamin D Supplementation in Pregnancy .............................................. 10 Appendix 2: Fact Sheet: Vitamin D Insufficiency / Deficiency in Pregnancy ................................. 10 Appendix 2: Parent information: Vitamin D Deficiency in Babies .................................................. 12 Summary of Practice Recommendations All women should be screened for risk factors at their first antenatal visit. All women not at risk of vitamin D deficiency should commence colecalciferol 400 units daily as part of routine supplementation. Women at risk of vitamin D deficiency should have blood taken for 25-hydroxy vitamin D level Women at risk of vitamin D deficiency should commence 1,000 units (25 micrograms) of colecalciferol per day. Subsequent management of women and their babies is dependent on 25-OHD levels at 28 weeks gestation. Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 5 of 14 Public-I2-A2 Abbreviations AI Adequate intake a.m. Ante meridiem (before noon) BMI Body mass index (kg/m2) e.g. For example et al. And others MED Minimal erythemal dose mL Millilitre(s) nmol/L Nanomoles per litre 25-OHD 25-hydroxy-vitamin D PTH Parathyroid hormone p.m. Post meridiem (after noon) Vit Vitamin Definitions Vitamin D sufficiency Serum 25-OHD levels >50 nmol/L Vitamin D insufficiency Serum 25-OHD levels of 30 to 50 nmol/L Vitamin D deficiency Serum 25-OHD levels <30 nmol/L Introduction Vitamin D plays an essential role in calcium metabolism, bone growth and mineralisation Around 90 % of our vitamin D requirement comes from exposure of the skin to sunlight. The average diet contains only about 10 % of our requirements insufficient to prevent vitamin D deficiency1. The highest rates of vitamin D deficiency occur in dark-skinned, veiled, pregnant women (80%), with similarly high rates found in mothers of infants treated for rickets2,3. High rates of vitamin D deficiency have been found in low risk South Australian antenatal populations, with risk-based screening failing to detect over half of deficient women4. BMI is inversely proportional to serum vitamin D levels, with one study showing a BMI ?40 was associated with a 24% lower serum 25-OHD (25-hydroxy-vitamin D) level compared to those with BMI <255. Women with darker skin produce less vitamin D for a given sunlight exposure6,7. Neonatal vitamin D deficiency is always caused by maternal deficiency8. Food sources of Vitamin D Few foods contain significant amounts of vitamin D (e.g. fish with a high fat content such as salmon, tuna, herring, mackerel and sardines). Other sources include meat, milk and eggs In Australia, some margarine and milk and milk products are fortified with vitamin D2. Breast milk is an inadequate source of vitamin D and exclusive breastfeeding is a risk factor for neonatal rickets8. Other sources of Vitamin D The optimum route of vitamin D intake is via skin exposure. However, deliberate sun exposure between 10.00 a.m. and 2.00 p.m. in summer (11.00 a.m. and 3:00 p.m. daylight saving time) is not advised3. Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 6 of 14 Public-I2-A2 It has been shown that whole body exposure to 10-15 minutes of midday sun in summer (about 1 minimal erythemal dose [MED] or the amount of sun exposure that just produces a faint redness of skin) is comparable to taking 15,000units (375 micrograms) of vitamin D (colecalciferol) orally3. On this basis, exposure of hands, face and arms (around 15 % of body surface) to around 1/3 MED should produce around 1,000units of vitamin D (colecalciferol) for people with moderately fair skin3. Exposure times for people with highly pigmented skin would be 3-4 times greater3. Vitamin D content of multivitamins A large proportion of women take multivitamins in pregnancy9. The vitamin D content of commonly used pregnancy multivitamins are as follows: > Blackmores Pregnancy & Breastfeeding Gold o 500units per capsule = 1000units/day (i.e. 2 tablets) > Elevit Pregnancy Multivitamin o 200 units per tablet = 200units/day > Swisse Pregnancy + Ultivite o 600units per capsule = 600units/day Vitamin D status in pregnancy Recent consensus guidelines recommend the following classification of vitamin D status8. These are in line with those already in use by The Royal Australian and New Zealand College of Obstetricians and Gynaecologists10. > Vitamin D sufficiency o Serum 25-OHD levels >50 nmol/L > Vitamin D insufficiency o Serum 25-OHD levels of 30 to 50 nmol/L > Vitamin D deficiency o Serum 25-OHD levels <30 nmol/L Women with vitamin D insufficiency/deficiency are at risk of: > Osteomalacia > Accelerated osteoporosis due to secondary hyperparathyroidism > Muscle weakness Vitamin D insufficiency/deficiency in pregnancy may be associated with: > Hypertension > Pre-eclampsia > Increased primary Caesarean section rates11 Babies of women with vitamin D insufficiency/deficiency during pregnancy are at risk of: > Hypocalcaemia and seizures > Rickets > Myopathy > Reduced intrauterine long bone growth12 Although there is some evidence for risk reduction with vitamin D supplementation, further randomised controlled trials are required to confirm the benefits13. Despite this, a strategy for supplementation and treatment of maternal vitamin D deficiency is recommended10,11. Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 7 of 14 Public-I2-A2 Antenatal screening and treatment First appointment (booking) screening of at risk women Pregnant women at risk of vitamin D insufficiency/deficiency (see below) are to be offered vitamin D screening at booking. They include: > All veiled women e.g. Muslim, including those wearing headscarves > Darker skinned women e.g. Aboriginal, North African, Indian and Sri Lankan > Newly arrived refugees > Women with limited sun exposure for any reason e.g. night shift or office workers Vitamin D supplementation for ALL pregnant women Pregnant women without known risk factors Commence colecalciferol 400 units daily as part of routine supplementation e.g. 0.2ml Ostelin Vitamin D Liquid (1,000 units/0.5ml) or half tablet of OsteVit-D (equivalent to 500 units) (which may be purchased from a community pharmacy without a prescription). See appendix 1 for information for women. Note: Also consider the vitamin D content of the woman s pregnancy multivitamin, then supplement if required. Pregnant women with known risk factors Request blood 25-hydroxy vitamin D (25-OHD) level Commence 1,000 units (25 micrograms) of colecalciferol daily (e.g. one capsule of Ostelin , one tablet of OsteVit-D or 0.5mL Ostelin Vitamin D Liquid (1,000 units/0.5ml) (which may be purchased from a community pharmacy without a prescription). See appendix 2 for information for women. Note: Also consider the vitamin D content of the woman s pregnancy multivitamin and then adjust the supplement if required. First follow-up of at risk women Check the report of the original 25-OHD assay at the next appointment: Vitamin D ?50 nmol/L > Continue vitamin D 1,000 units daily > Repeat 25-OHD level at 28/40 to see if it has normalised Vitamin D > 50 nmol/L > Decrease vitamin D to 400 units daily Subsequent follow-up of at risk women Depending on the second 25-OHD assay: If 25OHD > 50 nmol/L > Continue vitamin D 1,000 units daily If 25OHD ? 50 nmol/L > Increase dose to vitamin D 2,000 units daily Discharge All at risk women require a follow-up letter to their General Practitioner with a recommendation for a repeat 25-OHD assay at 6 weeks and vitamin D should be resumed then if indicated. Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 8 of 14 Public-I2-A2 Neonatal management Universal supplementation of infants with vitamin D is recommended in global consensus guidelines8. However, Australian and New Zealand guidelines recommend targeted supplementation of infants with the following risk factors: maternal vitamin D deficiency, exclusive breast feeding, and dark skin and/or social or cultural factors that could lead to lack of exposure to sunlight14. The following considerations are the basis for recommendations for neonatal supplementation, taking into account published recommendations and an approach to protocol implementation that optimises adherence and minimises harm. See appendix 3 for information for parents. > In the absence of maternal risk factors (women not normally screened and are receiving 400units of colecalciferol), babies do not need routine vitamin D supplementation. > Vitamin D supplementation at 400units daily is safe in babies. There is a wide therapeutic safety window for 25-OHD in neonates, with toxicity unlikely below levels of 250nmol/L14. > Breast milk vitamin D content approximates 4units per 100mL15, and term infant formula (fortified with vitamin D) approximates 40units per 100mL (typical range 30-48units referenced from manufacturer labelling). Daily intake from formula is unlikely to meet the recommended adequate intake (AI is 400units assuming minimal sun exposure), whereas the addition of 400units daily supplement is unlikely to cause toxicity. > Supplementation of both breast milk and formula fed babies with risk factors increases the simplicity of the protocol, and may reduce a maternal perception that breast milk is inadequate. > Even if maternal vitamin D sufficiency is assumed at full term on the basis of supplementation and normal maternal 25-0HD levels, the lifestyle, social and cultural factors that affected the mother may persist after the baby s birth and impact the baby. Supplementation based on risk factors even if maternal supplementation has normalised maternal levels is reasonable. > Serum 25-OHD levels are not generally measured in babies <3 months of age. However where a clinician has measured 25-OHD levels, definitions of deficiency and treatment follow the SA Paediatric Clinical Practice Guideline: Vitamin D Deficiency in Children (available at www.sahealth.sa.gov.au/paediatric) and the SA Neonatal Medication Guidelines: Colecalciferol and Multivitamins (available at www.sahealth.sa.gov.au/neonatal). > Sunlight exposure in babies needs to balance risks of skin damage with the benefit of vitamin D synthesis and no firm recommendations can be made. The following suggested advice to parents is modified from the ANZ position statement14. Light to olive skin Brown, dark brown and black skin UV index ?3 Full protection advised sunscreen, hat, clothing, shade Hat, clothing, shade, intermittent sun exposure of arms and legs without sunscreen for approximately 10-15 minutes per day encouraged UV index <3 Sunscreen not required. Intermittent sun exposure of arms and legs for 10-15 minutes encouraged. Encourage sun exposure of arms and legs during outdoor activity Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 9 of 14 Public-I2-A2 References 1. Nozza JM, Rodda CP. Vitamin D deficiency in mothers of infants with rickets. MJA 2001; 175: 253-255. Available at URL: http://www.mja.com.au/public/issues/175_05_030901/nozza/nozza.html 2. Nowson CA, Margerison C. Vitamin D intake and vitamin D status of Australians. MJA 2002; 177: 149-152. Available at URL: http://www.mja.com.au/public/issues/177_03_050802/now10763_fm.html 3. Diamond TH, Eisman JA, Mason RS, Nowson CA, Pasco JA, et al. Working Group of the Australian and New Zealand Bone and Mineral Society, Endocrine Society of Australia and Osteoporosis Australia. Vitamin D and adult bone health in Australia and New Zealand: a position statement. MJA 2005; 182: 281-285. Available at URL: http://www.mja.com.au/public/issues/182_06_210305/dia10848_fm.html 4. De Laine KM, Matthews G, Grivell RM. Propspective audit of vitamin D levels of women presenting for their first antenatal visit. Aust N Z J Obstet Gynaecol. 2013 Aug;53(4):353-7. Available at URL: https://doi.org/10.1111/ajo.12052 5. Konradsen S, Ah H, Lindberg F, Hexeberg S, R. J. Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr. 2008;47(2). Available at URL: http://www.ncbi.nlm.nih.gov/pubmed/18320256 6. Grover SR, Morley R. Vitamin D deficiency in veiled or dark-skinned pregnant women. MJA 2001; 175: 251-252. Available at URL: http://www.mja.com.au/public/issues/175_05_030901/grover/grover.html 7. McCullough ML. Vitamin D deficiency in pregnancy: Bringing the issues to light. J Nutrition 2007; 137: 305-306. 8. Munns C, Shaw N, Kiely M, Specker B, Thacher T et al. Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. JCEM 2016; 101(2): 394-415. Available at URL: http://press.endocrine.org/doi/pdf/10.1210/jc.2015-2175 9. Sullivan KM, Ford ES, Fuad Azrak M, Mokdad AH. Multivitamin Use in Pregnant and Nonpregnant Women: Results from the Behavioral Risk Factor Surveillance System. Public Health Rep. 2009 May-Jun; 124(3): 384 390. Available at URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663874/ 10. The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Vitamin and mineral supplementation and pregnancy. RANZCOG 2015. Available at URL: https://www.ranzcog.edu.au/RANZCOG_SITE/media/RANZCOG- MEDIA/Women%27s%20Health/Statement%20and%20guidelines/Clinical-Obstetrics/Vitamin- and-mineral-supplementation-in-pregnancy-(C-Obs-25)-Review-Nov-2014,-Amended-May- 2015.pdf?ext=.pdf 11. Royal College of Obstetricians and Gynaecologists. Vitamin D in Pregnancy (Scientific Impact Paper No.43). 2014. Available at URL: https://www.rcog.org.uk/globalassets/documents/guidelines/scientific-impact- papers/vitamin_d_sip43_june14.pdf. 12. Morley R, Carlin JB, Pasco JA, Wark JD. Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab 2006; 91: 906-912. 13. De-Regil LM, Palacios C, Lombardo LK, Pe a-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD008873. DOI: 10.1002/14651858.CD008873.pub3. Available at URL: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008873.pub3/pdf 14. Paxton GA, Teale GR, Nowson CA, Mason RS, McGrath JJ, Thompson MJ, Siafarikas A, Rodda CP and Munns CF. Vitamin D and health in pregnancy, infants, children and adolescents in Australia and New Zealand: a position statement. MJA 2013; 198 (3): 142-143. Available at URL: https://www.mja.com.au/journal/2013/198/3/vitamin-d-and-health-pregnancy-infants-children-and- adolescents-australia-and 15. National Health and Medical Research Council. Eat for Health Infant Feeding Guidelines Information for health workers. Canberra: NHMRC, 2012. Available at URL: https://nhmrc.gov.au/about-us/publications/infant-feeding-guidelines-information-health-workers Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 10 of 14 Public-I2-A2 Appendix I: Fact Sheet: Vitamin D Supplementation in Pregnancy Fact Sheet Routine Vitamin D Supplementation in Pregnancy About Vitamin D Vitamin D is needed to keep bones healthy and strong. > Most (90%) vitamin D comes from exposing your skin to the sun. A balance of sun exposure and sun protection is needed to make enough Vitamin D. > Some (10%) vitamin D comes from food such as oily fish, meat, milk and eggs. What happens if you do not have enough vitamin D? Many people with low vitamin D do not have symptoms. Vitamin D deficiency can cause: > Rickets (soft bones) in children > Muscle cramps > Seizures (fits) due to low calcium Low vitamin D may be linked to other health problems such as: a higher risk of bowel cancer, heart disease, problems with immunity (how the body fights infections) and autoimmune diseases (e.g. diabetes). Vitamin D supplementation Routine supplementation with Vitamin D (400units daily) is recommended for all pregnant women. This can be achieved by a vitamin D supplement which may be purchased from a community pharmacy without a prescription e.g. > 0.2ml Ostelin Vitamin D Liquid (1,000 units/0.5ml) or > half tablet of OsteVit-D (equivalent to 500 units) You may be taking a pregnancy multivitamin already, however the vitamin D content varies so you may need additional supplementation. The vitamin D content of commonly used pregnancy multivitamins is as follows: > Blackmores Pregnancy & Breastfeeding Gold o 500units per capsule = 1000 units/day (i.e. 2 tablets) > Elevit Pregnancy Multivitamin o 200 units per tablet = 200 units/day > Swisse Pregnancy + Ultivite o 600units per capsule = 600 units/day Further Information 1. Well for Life https://www.betterhealth.vic.gov.au/health/HealthyLiving/vitamin-d 2. NHMRC Nutrient Reference Values for Australia and NZ Vitamin D www.nrv.gov.au/nutrients/vitamin-d Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 11 of 14 Public-I2-A2 Appendix 2: Vitamin D Deficiency in Pregnancy Fact Sheet Vitamin D Insufficiency / Deficiency in Pregnancy About Vitamin D Vitamin D is needed to keep bones healthy and strong. > Most (90%) vitamin D comes from exposing your skin to the sun. A balance of sun exposure and sun protection is needed to make enough Vitamin D. > Some (10%) vitamin D comes from food such as oily fish, meat, milk and eggs. What happens if you do not have enough vitamin D? Many people with low vitamin D do not have symptoms. Vitamin D deficiency can cause: > Rickets (soft bones) in children > Muscle cramps > Seizures (fits) due to low calcium Low vitamin D may be linked to other health problems such as: a higher risk of bowel cancer, heart disease, problems with immunity (how the body fights infections) and autoimmune diseases (e.g. diabetes). Vitamin D supplementation Supplementation with vitamin D (1000units) is recommended for women with risk factors or whose vitamin D level is known to be low. This can be achieved by a vitamin D supplement which may be purchased from a community pharmacy without a prescription e.g. > 0.5mL Ostelin Vitamin D Liquid (1,000 units/0.5mL) or > One tablet of OsteVit-D (1,000 units) or > One capsule of Ostelin Vitamin D (1,000 units) You may be taking a pregnancy multivitamin already, however the vitamin D content varies so you may need additional supplementation. The vitamin D content of commonly used pregnancy multivitamins is as follows: > Blackmores Pregnancy & Breastfeeding Gold o 500units per capsule = 1000 units/day (i.e. 2 tablets) > Elevit Pregnancy Multivitamin o 200 units per tablet = 200 units/day > Swisse Pregnancy + Ultivite o 600units per capsule = 600 units/day Further Information 1. Well for Life https://www.betterhealth.vic.gov.au/health/HealthyLiving/vitamin-d 2. NHMRC Nutrient Reference Values for Australia and NZ Vitamin D www.nrv.gov.au/nutrients/vitamin-d Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 12 of 14 Public-I2-A2 Appendix 2: Parent information: Vitamin D Deficiency in Babies Parent Information Vitamin D Deficiency in Babies About Vitamin D Vitamin D is needed to keep bones healthy and strong. > Most (90%) vitamin D comes from exposing your skin to the sun. A balance of sun exposure and sun protection is needed to make enough Vitamin D. > Some (10%) vitamin D comes from food such as oily fish, meat, milk and eggs. What happens if you do not have enough vitamin D? Many people with low vitamin D do not have symptoms. Vitamin D deficiency can cause: > Rickets (soft bones) in children > Muscle cramps > Seizures (fits) due to low calcium Low vitamin D may be linked to other health problems such as: a higher risk of bowel cancer, heart disease, problems with immunity (how the body fights infections) and autoimmune diseases (e.g. diabetes). Breast Feeding Breast feeding is the best way to feed your baby. Breast feeding is important for your baby s health and wellbeing. You can still breast feed your baby if your Vitamin D level is low. Vitamin D Supplementation for Babies All breastfed and formula fed babies born to mothers who have had persistently low vitamin D levels in pregnancy or who are at risk of vitamin D deficiency (e.g. due to darker skin colour, veiled), should be given a 400 units daily vitamin D supplement for the first 12 months of life. The preparations used in SA hospitals are Ostelin Vitamin D Liquid (1,000units/0.5mL) and Penta-vite Infant Drops . Ostelin Vitamin D Liquid (1,000units/0.5mL) Ostelin Vitamin D Liquid contains vitamin D. The dose is 0.2mL daily, and it is the preferred vitamin D liquid in term babies as it tastes better than Penta-vite Infant Drops . You can buy a bottle of Ostelin Vitamin D Liquid from your local chemist. Penta-vite Infant Drops Penta-vite Infant Drops contain vitamins A, B1, B2, B3, B6, C and D. The dose is 0.45mL daily. You can buy a bottle of Penta-vite Infant Drops from your local chemist. Further Information Speak with your GP (General Practitioner) if you have any questions about your or your baby s Vitamin D levels. 1. Well for Life https://www.betterhealth.vic.gov.au/health/HealthyLiving/vitamin-d 2. NHMRC Nutrient Reference Values for Australia and NZ Vitamin D www.nrv.gov.au/nutrients/vitamin-d Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 13 of 14 Public-I2-A2 Acknowledgements The South Australian Perinatal Practice Guidelines gratefully acknowledge the contribution of clinicians and other stakeholders who participated throughout the guideline development process particularly: Write Group Lead Dr Kate Gowling Write Group Members A/Prof Rosalie Grivell Catherine Leggett Dr Scott Morris Rebecca Smith Sheree Wynne Other contributors Dr Feisal Chenia Cassandra Mosel SAPPG Management Group Members 2018 SAPPG Management Group Members Sonia Angus Dr Kris Bascomb Lyn Bastian Elizabeth Bennett Dr Feisal Chenia John Coomblas A/Prof Rosalie Grivell Dr Sue Kennedy-Andrews Jackie Kitschke Catherine Leggett Dr Anupam Parange Dr Andrew McPhee Rebecca Smith A/Prof John Svigos Dr Laura Willington Vitamin D Status in Pregnancy INFORMAL COPY WHEN PRINTED Page 14 of 14 Public-I2-A2 Document Ownership & History Developed by: SA Maternal, Neonatal & Gynaecology Community of Practice Contact: HealthCYWHSPerinatalProtocol@sa.gov.au Endorsed by: SA Health Safety and Quality Strategic Governance Committee Next review due: 10/05/2024 ISBN number: 978-1-76083-126-4 PDS reference: CG251 Policy history: Is this a new policy (V1)? N Does this policy amend or update and existing policy? Y If so, which version? 3 Does this policy replace another policy with a different title? Y If so, which policy (title)? Vitamin D Deficiency Approval Date Version Who approved New/Revised Version Reason for Change 10/05/2019 V4 SA Health Safety and Quality Strategic Governance Committee Formally reviewed 24/12/2007 V3 SA Maternal & Neonatal Clinical Network Minor amendment 20/09/2007 V2 SA Maternal & Neonatal Clinical Network Minor amendment 18/09/2007 V1 SA Maternal & Neonatal Clinical Network Original SA Maternal & Neonatal Clinical Network approved version. Purpose and Scope of Perinatal Practice Guideline (PPG) Flowchart 1: Management of Vitamin D Status in Pregnancy Flowchart 2: Newborn Management Abbreviations Definitions Introduction Food sources of Vitamin D Other sources of Vitamin D Vitamin D content of multivitamins Vitamin D status in pregnancy Antenatal screening and treatment First appointment (booking) screening of at risk women Vitamin D supplementation for ALL pregnant women First follow-up of at risk women Subsequent follow-up of at risk women Discharge Neonatal management References Appendix I: Fact Sheet: Vitamin D Supplementation in Pregnancy Appendix 2: Vitamin D Deficiency in Pregnancy Appendix 2: Parent information: Vitamin D Deficiency in Babies </pre> </body> </html>