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Version control and change history
Version Date from Date to Amendment
1.0 July 2013 Aug 2017 Original version
2.0 11 Aug 2017 Current Change in formulation
Department for Health and Ageing, Government of South Australia. All rights reserved.
Clinical Guideline
Vitamin E
Policy developed by: SA Maternal, Neonatal & Gynaecology Community of
Practice
Approved SA Health Safety & Quality Strategic Governance Committee on:
11 August 2017
Next review due: 31 August 2020
Summary The purpose of this guideline is to guide nursing, midwifery,
medical and pharmacy staff in the dosing and administration of
vitamin E for vitamin E deficiency, oxidative haemolysis in preterm
infants or chronic cholestasis
Keywords Vitamin e, neonatal medication guideline, dl-alpha-tocopherol
acetate, dl-alpha-tocopherol, haemolysis, cholestasis
Policy history Is this a new policy? N
Does this policy amend or update an existing policy? Y v1.0
Does this policy replace an existing policy? N
If so, which policies? Vitamin E 115mg/mL oral mixture
Neonatal Medication Guideline
Applies to All Health Networks
CALHN, SALHN, NALHN, CHSALHN, WCHN, SAAS
Staff impact All Clinical, Medical, Midwifery, Nursing, Students, Allied Health,
Emergency, Mental Health, Pathology, Pharmacy
PDS reference CG0265
Neonatal Medication Guideline
South Australian Neonatal Medication Guidelines
Vitamin E
104.7mg/mL oral mixture
Department of Health, Government of South Australia. All rights reserved
ISBN number: 978-1-74243-545-9
Endorsed by: South Australian Maternal, Neonatal & Gynaecology Community of Practice
Last Revised: 11/8/17
Contact: South Australian Neonatal Medication Guidelines Workgroup at:
NeoMed@health.sa.gov.au Page 1 of 2
Note
This guideline provides advice of a general nature. This statewide guideline has been prepared to promote and facilitate
standardisation and consistency of practice, using a multidisciplinary approach. The guideline is based on a review of
published evidence and expert opinion.
Information in this statewide guideline is current at the time of publication.
SA Health does not accept responsibility for the quality or accuracy of material on websites linked from this site and does not
sponsor, approve or endorse materials on such links.
Health practitioners in the South Australian public health sector are expected to review specific details of each patient and
professionally assess the applicability of the relevant guideline to that clinical situation.
If for good clinical reasons, a decision is made to depart from the guideline, the responsible clinician must document in the
patient s medical record, the decision made, by whom, and detailed reasons for the departure from the guideline.
This statewide guideline does not address all the elements of clinical practice and assumes that the individual clinicians are
responsible for discussing care with consumers in an environment that is culturally appropriate and which enables respectful
confidential discussion. This includes:
The use of interpreter services where necessary,
Advising consumers of their choice and ensuring informed consent is obtained,
Providing care within scope of practice, meeting all legislative requirements and maintaining standards of
professional conduct, and
Documenting all care in accordance with mandatory and local requirements
Synonyms
dl-alpha-tocopherol acetate
dl-alpha-tocopherol
Note
Vitamin E liquid (Micel E Pretorius
) contain 104.7mg/mL of dl-alpha-tocopherol acetate
(equivalent to 156units of dl-alpha-tocopherol acetate).
Dose and Indications
For prevention of vitamin E deficiency in preterm infants < 2000g at birth or
< 34 weeks gestation
Oral
10.5mg (0.1mL) ONCE daily
To be commenced when tolerating enteral feeds of 150mL/kg daily.
Continue until term corrected age OR until discharge if this is earlier.
For treatment of oxidative haemolysis in preterm neonates
Oral
21mg (0.2mL) ONCE daily
South Australian Neonatal Medication Guidelines
Vitamin E
104.7mg/mL oral mixture
ISBN number: 978-1-74243-545-9
Endorsed by: South Australian Maternal, Neonatal & Gynaecology Community of Practice
Last Revised: 11/8/2017
Contact: South Australian Neonatal Medication Guidelines Workgroup at:
NeoMed@health.sa.gov.au Page 2 of 2
Version control and change history
PDS reference: OCE use only
Version Date from Date to Amendment
1.0 July 2013 Aug 2017 Original version
2.0 11 Aug 2017 Current Change to formulation
Chronic Cholestasis
Oral
42mg (0.4mL) ONCE daily
To be commenced when tolerating enteral feeds of 150mL/kg daily.
Continue until conjugated bilirubin normalises
Preparation and Administration
Oral
Oral mixture contains 104.7mg/mL
Dose 10.5mg 21mg 42mg
Volume 0.1mL 0.2mL 0.4mL
Give with feeds to reduce gastrointestinal irritation
Adverse Effects
Feeding intolerance may occur due to hyperosmolarity of preparation.
Monitoring
? Assess feeding tolerance
Practice Points
? Can dilute with sterile water or formula to reduce the osmolarity.
? Do not administer with iron as iron absorption may be reduced, doses need to be
separated by at least 2 hours.
? 1mg dl-alpha-tocopherol acetate = 1.5 international units of vitamin E.
Vitamin E_Neo_Cover_v2_0
Clinical Guideline
Vitamin E
Policy developed by: SA Maternal, Neonatal & Gynaecology Community of Practice
Approved SA Health Safety & Quality Strategic Governance Committee on:
11 August 2017
Next review due: August 2020
Vitamin E_Neo_v2_0
Vitamin E_Neo_Cover_v2_0.pdf
Clinical Guideline
Vitamin E
Policy developed by: SA Maternal, Neonatal & Gynaecology Community of Practice
Approved SA Health Safety & Quality Strategic Governance Committee on:
11 August 2017
Next review due: 31 August 2020
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