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Version control and change history 
 
Version Date from Date to Amendment 
1.0 July 2013 Aug 2017 Original version 
2.0 11 Aug 2017 Current Change in formulation 
    
    

  Department for Health and Ageing, Government of South Australia. All rights reserved. 

 

Clinical Guideline 
Vitamin E 
 
 
Policy developed by: SA Maternal, Neonatal &amp; Gynaecology Community of 
Practice       
Approved SA Health Safety &amp; Quality Strategic Governance Committee on:   
   11 August 2017  
Next review due:    31 August 2020 
 
 
 

  
 
 

Summary The purpose of this guideline is to guide nursing, midwifery, 
medical and pharmacy staff in the dosing and administration of 
vitamin E for vitamin E deficiency, oxidative haemolysis in preterm 
infants or chronic cholestasis 
 

Keywords Vitamin e, neonatal medication guideline,  dl-alpha-tocopherol 
acetate,  dl-alpha-tocopherol, haemolysis, cholestasis 
 

Policy history Is this a new policy?   N 
Does this policy amend or update an existing policy?  Y v1.0 
Does this policy replace an existing policy?  N 
If so, which policies?  Vitamin E 115mg/mL oral mixture 
Neonatal Medication Guideline 
 

Applies to All Health Networks 
CALHN, SALHN, NALHN, CHSALHN, WCHN, SAAS 
 

Staff impact All Clinical, Medical, Midwifery, Nursing,  Students, Allied Health, 
Emergency, Mental Health, Pathology, Pharmacy 
  

  
PDS reference CG0265 

Neonatal Medication Guideline                                                             
 

 



South Australian Neonatal Medication Guidelines 

Vitamin E  
 104.7mg/mL oral mixture 

  Department of Health, Government of South Australia. All rights reserved 

 

ISBN number: 978-1-74243-545-9 
Endorsed by: South Australian Maternal, Neonatal &amp; Gynaecology Community of Practice  
Last Revised: 11/8/17 
Contact:                                 South Australian Neonatal Medication Guidelines Workgroup at: 

 NeoMed@health.sa.gov.au  Page 1 of 2 
 

Note 
 
This guideline provides advice of a general nature.  This statewide guideline has been prepared to promote and facilitate 
standardisation and consistency of practice, using a multidisciplinary approach.  The guideline is based on a review of 
published evidence and expert opinion.  

Information in this statewide guideline is current at the time of publication.  

SA Health does not accept responsibility for the quality or accuracy of material on websites linked from this site and does not 
sponsor, approve or endorse materials on such links. 

Health practitioners in the South Australian public health sector are expected to review specific details of each patient and 
professionally assess the applicability of the relevant guideline to that clinical situation. 

If for good clinical reasons, a decision is made to depart from the guideline, the responsible clinician must document in the 
patient s medical record, the decision made, by whom, and detailed reasons for the departure from the guideline. 

This statewide guideline does not address all the elements of clinical practice and assumes that the individual clinicians are 
responsible for discussing care with consumers in an environment that is culturally appropriate and which enables respectful 
confidential discussion. This includes: 

  The use of interpreter services where necessary, 
  Advising consumers of their choice and ensuring informed consent is obtained, 
  Providing care within scope of practice, meeting all legislative requirements and maintaining standards of 

professional conduct, and  
  Documenting all care in accordance with mandatory and local requirements 
 
 

Synonyms 

dl-alpha-tocopherol acetate 

dl-alpha-tocopherol  

Note 

Vitamin E liquid (Micel E Pretorius
 
) contain 104.7mg/mL of dl-alpha-tocopherol acetate 

(equivalent to 156units of dl-alpha-tocopherol acetate). 

Dose and Indications 

For prevention of vitamin E deficiency in preterm infants &lt; 2000g at birth or 

&lt; 34 weeks gestation 

Oral 

10.5mg (0.1mL) ONCE daily 

To be commenced when tolerating enteral feeds of 150mL/kg daily. 

Continue until term corrected age OR until discharge if this is earlier. 

For treatment of oxidative haemolysis in preterm neonates  

Oral 

21mg (0.2mL) ONCE daily 

  



South Australian Neonatal Medication Guidelines 

 Vitamin E  
 104.7mg/mL oral mixture 

 

ISBN number: 978-1-74243-545-9 
Endorsed by: South Australian Maternal, Neonatal &amp; Gynaecology Community of Practice 
Last Revised: 11/8/2017 
Contact: South Australian Neonatal Medication Guidelines Workgroup at:         

 NeoMed@health.sa.gov.au  Page 2 of 2 
 

Version control and change history 

PDS reference: OCE use only 

 
Version Date from Date to Amendment 

1.0 July 2013 Aug 2017 Original version 

2.0 11 Aug 2017 Current Change to formulation 

    

    

 
 

Chronic Cholestasis 

Oral 

42mg (0.4mL) ONCE daily 

To be commenced when tolerating enteral feeds of 150mL/kg daily.  

Continue until conjugated bilirubin normalises 

Preparation and Administration 

Oral 

Oral mixture contains 104.7mg/mL 

Dose 10.5mg 21mg 42mg 

Volume 0.1mL 0.2mL 0.4mL 

Give with feeds to reduce gastrointestinal irritation 

Adverse Effects 

Feeding intolerance may occur due to hyperosmolarity of preparation.  

Monitoring  

? Assess feeding tolerance 

Practice Points 

? Can dilute with sterile water or formula to reduce the osmolarity.  

? Do not administer with iron as iron absorption may be reduced, doses need to be 

separated by at least 2 hours. 

? 1mg dl-alpha-tocopherol acetate = 1.5 international units of vitamin E. 


	Vitamin E_Neo_Cover_v2_0
	Clinical Guideline
	Vitamin E
	Policy developed by: SA Maternal, Neonatal &amp; Gynaecology Community of Practice
	Approved SA Health Safety &amp; Quality Strategic Governance Committee on:
	11 August 2017
	Next review due:   August 2020

	Vitamin E_Neo_v2_0
	Vitamin E_Neo_Cover_v2_0.pdf
	Clinical Guideline
	Vitamin E
	Policy developed by: SA Maternal, Neonatal &amp; Gynaecology Community of Practice
	Approved SA Health Safety &amp; Quality Strategic Governance Committee on:
	11 August 2017
	Next review due:    31 August 2020


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