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High risk medicines

High risk medicines are those medicines that have a high risk of causing significant patient harm or death when used in error. Although errors may or may not be more common than with other medicines, the consequences of errors with these medicines can be more devastating. To assist in preventing errors, SA Health’s High Risk Medicines safety initiative has put together a set of safety tips for specific high risk medicines.  

Special safeguards to minimise opportunities for errors are integral to patient safety. 

eLearning for SA Health staff

If you work at SA Health, you can utilise SA Health's eLearning modules to learn more about:

Standards and policy directives

Organisations are required to implement systems to reduce the occurrence of medication incidents and improve the safety and quality of medicines use in accordance with National Safety and Quality Health Service (NSQHS) Standard 4 – Medication Safety.

New oral anticoagulants (NOAC) - apixaban, rivaroxaban and dabigatran

NOAC are indicated for the prevention of systemic embolism in selected patients with non-valvular atrial fibrillation (AF) and for the prevention and/or treatment of venous thromboembolism (VTE). Due to the nature of the medicines the following clinical guidelines have been developed:

High Risk Medicines Management

To assist organisations to meet the NSQHS Standards, SA Health has developed a High Risk Medicines Management Policy Directive (PDF 493KB). This directive and its associated High Risk Medicines Management Guideline (PDF 629KB) aim to improve patient safety and reduce harm within the domains of storage, prescribing, dispensing and administration of identified high risk medicines and assist organisations achieve these goals.

Compliance with this policy is mandatory and will ensure a standard approach to high risk medicines and support clinical staff in their safe management.

 

APINCH and high risk medicines

The acronym APINCH is often used to classify high risk medicines.

The most common high risk medicines reported are included in the ISMP ‘High Alert Medications’ and A PINCH lists.

A Anti-infectives Amphotericin, vancomycin, and aminoglycosides, but may also include others
P Potassium and concentrated electrolytes Injectable electrolyte preparations, for example potassium chloride and magnesium sulphate, but may also include other medicines
I Insulin All insulins
N Narcotics and sedatives All opioids, sedatives may include benzodiazepines and other sedating agents
C Chemotherapy agents Cytotoxic chemotherapy
H Heparin and other anticoagulants Heparins and all anticoagulants, including the New Oral Anticoagulants

APINCH listed medications and their associated best practice tools and recommendations

The APINCH list is not exhaustive and other individual medicines or groups, for example, neuromuscular blocking agents used in general anaesthesia should be included.

Alerts

South Australian high risk medication safety alerts and notices

See Medication safety alerts page.

National High Risk Medication Safety Alerts

Potassium

The use and storage of concentrated intravenous potassium chloride ampoules in patient care areas is well documented in international and Australian literature as the root cause of fatal errors

See the national Medication Alert issued October 2003 for further information.

Vincristine

Inadvertent intrathecal administration of vincristine has been reported in Australia and overseas on several occasions. In the vast majority of cases, the outcome for the patient is fatal. Given the almost invariably fatal outcome of this error, prevention is of the utmost importance.

See the national Medication Alert issued December 2005 for further information.

Further information

For further information on previous alerts and high risk medicines email HealthMedicationSafety@sa.gov.au 

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