Clozapine is a medication used in the treatment of schizophrenia. It is an atypical antipsychotic and is regulated by the Therapeutic Goods Administration (TGA) and subsidised under the Highly Specialised Drugs Program.

Clozapine, tradename Clozaril® or Clopine®, may cause serious side effects in a very small proportion of the population especially if stopped abruptly or recommenced at the regular dose after a period of non-compliance, for instance in the event of a patient being admitted to hospital and not being able to tell staff that they are taking clozapine.

SA Mental Health Services are committed to providing clinicians and consumers with state wide standardised resources that will assist in the safe and effective management of consumers who are taking clozapine.

For more information

For information regarding clozapine management please contact the local clozapine coordinator at your nearest Community Mental Health Centre.

Resources for clinicians

Important information

Important information about patients on Clozapine - For general hospitals

Clozapine clinic journey (PDF 267KB)

Potential Clozapine drug interactions

Shared care pathways (PDF 360KB).

Alert instructions and screen captures

Clozapine Alert – Create/Update/Inactivate (OACIS alerts system) (PDF 460KB)

GP Clozapine screen captures (PDF 33KB)

Clozapine Review - CBIS screen captures (PDF 187KB)

Clozapine Alert - CBIS screen captures (PDF 89KB).

Flow charts

Flow chart – OACIS Alert for consumer on Clozapine admitted to general hospital ward (PDF 21KB)

Flow chart – Consumer on Clozapine admitted to ED (PDF 21KB)

Flow chart – Communication with community / inpatient Clozapine coordinators (PDF 22KB) 

Nurse-led clinic model (PDF 49MB).

Forms, protocol and guidelines

Clozapine prescription example (PDF 63KB)

Clozapine monitoring with cessation of tobacco use procedure (PDF 113KB)

Clozapine commencement procedure (PDF 133KB)

MR74D - Clozapine commencement guideline (PDF 197KB)

MR74D - Clozapine commencement form (PDF 256KB)

MR75D - Clozapine investigation review and prescription record guideline (PDF 80KB)

MR75D - Clozapine investigation review and prescription record form (PDF 80KB)

MR76D - Clozapine transfer of care guideline (PDF 168KB)

MR76D - Clozapine transfer of care form (PDF 303KB)

MR77D - Clozapine patient protocol - Monthly form guidelines (PDF 167KB)

MR77D - Clozapine patient protocol – Monthly form (PDF 166KB)

MR78D - Clozapine patient protocol - Recommencement guideline (PDF 96KB)

MR78D - Clozapine patient protocol - Recommencement form (PDF 175KB)

Nurse Led Clozapine Clinics – Pathways and protocols for managing abnormal / adverse events (PDF 89KB).

Information sheet

Factors Influencing Clozapine Plasma Concentrations (PDF 19KB)


Clozapine 'Lite' - education presentation (PDF 1.38MB)

Questionnaires and assessments

Nurse Led Clozapine Clinic - Questions to ask at Clozapine reviews (PDF 28KB)

Clozapine clinic consumer questionnaire (PDF 46KB)

Clozapine care card template (PDF 232KB)

Clozapine consumer body temperature information template (PDF 402KB)

GP information

Clozapine shared care checklist (PDF 127KB)

Resources for consumers

The resources listed below are information for people who have been prescribed clozapine and their carers. 

Clozapine clinic consumer questionnaire (PDF 42KB)

Clozapine consumer information brochure (PDF 433KB)

Clozapine guidelines for carers and support persons (PDF 305KB)

Shared care pathways (PDF 360KB).

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