Pharmacological management of symptoms for adults in the last days of life

All patients at the end of life are entitled to treatment to optimise their comfort and dignity. The treating team responsible for the care of a dying patient works together with the patient and their nominated carers/family members to ensure appropriate, timely and adequate treatment to prevent and relieve distress. This will often include prescribing medications for symptom management.

The Pharmacological Management of Symptoms for Adults in the Last Days of Life Clinical Guideline (PDF 632KB) recommends:

  • initial prescribing guidance for non-complex adult patients in the last days of life and likely to die in an acute setting or general hospital ward
  • common symptom medications, administration, and considerations for ceasing medications; seek specialist advice for complex cases
  • medications are only one aspect of symptom management and should be combined with non-pharmacological symptom management strategies
  • this guideline may also be useful in other care settings.

Anticipatory prescribing

There are several common symptoms that may cause distress in dying patients. Ordering medications ahead of time, 'anticipatory prescribing', is required so that prompt management of these symptoms can occur.

The SA Health quick reference guide - Prescribing guidelines for the pharmacological management of symptoms for adults in the last days of life (PDF 154KB) can be used in:

  • response to a patient suffering from distressing symptoms, and/or
  • anticipation of distressing symptoms developing.

Palliative care support line for clinicians

A statewide 24/7 palliative care support line is also available for clinician use only to receive advice regarding their patients from a Palliative Care Consultant.

Opioid dose conversions

Switch between opioid formulations

Therapeutic Guidelines: Palliative Care
Table 10.24 Approximate equianalgesic doses of opioids in palliative care
Access available through SALUS

Australian Medicines Handbook (AMH)
Opioid comparative information
Access available through SALUS

Faculty of Pain Medicine, Australian and New Zealand College of Anaesthetists
Opioid Dose Equivalence Calculation Table

Medication cessation

The Medication cessation for adults in the last days of life fact sheet (PDF 154KB) assists clinicians when considering which medications may be discontinued at the end of life and the potential withdrawal effects.

CareSearch is a web-based resource funded by the Australian Government to enhance the provision of palliative care and advance care planning. Resources available include: